I've just googled this issue that has brought me to here also, i'm having the same issue but just with the F100 at the moment. I press "Start Flight" and it instantly freezes, and have to use the Task Manager to get out of the Sim as you can't do anything. I did reinstall once, which did work for a while, but the issue came back and happened again 5 mins ago. I'll raise a Ticket too, but is can confirm it's not a one off.